Electroshock therapy is introduced in Rome and becomes widely used in treating severe depression.

In the film “The Snake Pit,” Olivia de Havilland finds herself in a terrifying insane asylum.

Lithium salts are first used for manicdepression.

In “The Three Faces Eve,” Joanne Woodward plays a wife with three separate personalities.

Valium is introduced in the U.S.

Sylvia Plath publishes “The Bell jar” in London.

Missouri Sen. Thomas Eagleton acknowledges having shock therapy for depression; Democrats drop him as VP candidate.

In “One Flew Over the Cuckoo’s Nest,” Jack Nicholson’s heroic McMurphy battles sadistic Nurse Ratched on a mental ward.

Actress Patty Duke reveals her manic-depression in an autobiography.

Eli Lilly & Co. introduces the antidepressant Prozac.

William Styron admits in The New York Times he suffered from severe depression.

Kitty Dukakis chronicles battle with mani-depression and substance abuse in her autobiography.

Therapy turns to romance between Barbra Streisand and Nick Nolte in “The Prince of Tides.”

Worldwide sales of Prozac exceed $1 billion. The antidepressant Zoloft goes on sale in the U.S.

Alma Powell reveals history of depression; husband Cohn, the general, urges others to get help.